Friday, 12th February

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Speakers

8:30AM - 10:30AM

Not available at time of printing - Gregory Goodall
Not available at time of printing - Vinay Tergaonkar
Cadherin 17 knockdown inactivates Wnt signaling pathway and induces apoptosis in colorectal cancer cells - Ishara Atukorala
Acute myeloid leukemia requires Hhex to enable PRC2-mediated epigenetic repression of Cdkn2a. - Matthew P McCormack
Targeting histone H3K36me3-deficient cancers - Timothy Humphrey

10:35AM - 11:00AM

Friday, 12th February

Exhibition Hall

11:00AM - 1:00PM

Friday, 12th February

Not available at time of printing - Helen Piwnica-Worms
Point mutations in promoter 1B of APC in a syndrome of gastric adenocarcinoma and proximal polyposis of the stomach - Susan L Woods
Exosomal shuttling of mutant β-catenin activates Wnt signaling pathway in the tumor microenvironment - Suresh Mathivanan
Not available at time of printing - Nic Waddell
Genomic catastrophes driving tumorigenesis in oesophageal adenocarcinoma - Andrew Barbour

1:00PM - 4:00PM

Friday, 12th February

Exhibition Hall

4:00PM - 5:35PM

Friday, 12th February

Identification of a myoepithelial protein that suppresses the DCIS to invasive carcinoma transition - Hendrika M Duivenvoorden
Chemokine receptor CXCR4 is required for progression of T cell acute lymphoblastic leukemia - Lauren A Pitt
CANCER AS A DISEASE OF THE SYMBIONT/METAORGANISM - Giorgio Trinchieri

6:25PM - 7:30PM

Friday, 12th February

7:30PM - 10:00PM

Friday, 12th February

Exhibition Hall

Uniform pattern of histone modifications define early stress induced drug tolerance in cancer - Abdullah Emran
Pancreatic cancer invasion and stromal remodelling is dependent on uPA and regulated by SerpinB2 - Nathanial L.E. Harris
Induction of miRNA124 Correlates with Inhibition of CDK4, CDK6 and EZH2 Expression and Epigenetic Treatment Response in Myeloid Malignancies - Hongbin Liu
A comprehensive meta analysis shows circulating miRNAs in gliomas as potential diagnostic biomarkers - Chenkai Ma
Sling shotting drugs into the brain to treat brain metastases - Joanna Macdonald
Combination drug therapies with the novel RNA Polymerase I inhibitor CX-5461 improve efficacy in the treatment of multiple myeloma - Kylee Maclachlan
Heparanase gene expression is regulated by the EWS-Fli1 fusion protein in Ewing sarcoma - Alyce J Mayfosh
MSH2 translocations are a androgen induced driver of clinically aggressive prostate cancer. - Patrick McCoy
Hormonally driven microRNAs as a key regulatory mechanism of the mismatch repair gene MSH2 in prostate cancer - Patrick J McCoy
Tamoxifen treatment of T47D breast cancer cells enhanced by hypoxia - Terri Meehan-Andrews
Effects of doxorubicin and ABT-737 on breast cancer: A real-time perspective - Terri Meehan-Andrews
Long-range regulation of HOTAIR identifies novel biomarkers of breast cancer outcome and suggests a role in genome instability - Michael J.G. Milevskiy
The structure and function of the EGF Receptor family members in Glioblastoma Multiforme - Ruth Mitchell
Intrinsic resistance to chemotherapy in lung adenocarcinoma - Ramyar Molania
Assessing the Contribution of Interleukin(s)-6 and -11 to Progression of Inflammatory Breast Cancer - Riley J Morrow
Neutrophils as therapeutic targets in metastatic breast cancer - Kellie Mouchemore
Identifying dormant breast cancer cells in the skeleton - Nancy Mourad
A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton - Marcia A Munoz
Understanding the anti-tumour potential of bisphosphonate drugs: effects on protein prenylation in macrophage populations in vivo - Marcia A Munoz
Gene expression of transcription factors FOXA1 and GATA3 in breast cancer - Anita Muthukaruppan
Molecular Interactions of Polo-like kinase 1 (PLK1) in Colorectal Cancer - Wayne Ng
Harnessing functional genomics to identify novel microRNA-based combination therapies in cancer - Iva Nikolic
RANK ligand as a target for breast cancer prevention in BRCA1-mutation carriers - Emma Nolan
INVESTIGATING THE MECHANISM UNDERLYING THE NUCLEOLAR STRESS RESPONSE AND ITS ROLE IN CANCER - Lorena Nunez
mTORC signalling is required for the proliferation of non-small cell lung cancer - Robert JJ O'Donoghue
Hck activity drives pulmonary inflammation and lung tumour progression in mice - Robert JJ O'Donoghue
LM511/β4 Integrin Autocrine Stimulation Regulates Triple Negative Breast Cancer Phenotype and Metastasis - Selda Onturk
Defective Intra-S Cell Cycle Checkpoint: A Potential Culprit and Target in Melanoma - Zay Yar Oo
Targeting JAK-kinases in colon cancer - Alex Owen
Nuclear PI3K Signalling in Colorectal Cancer - Michelle Palmieri
Identification of novel cancer genes predictive for prognosis and 5-FU benefit in colorectal cancer - Marie Parsons
Impact of Extracellular Matrix on Focal Adhesion Kinase in Breast Cancer - D. F. Thilini Perera
Skin Deep: Understanding Metastatic Cutaneous Squamous Cell Carcinoma - Jay Perry
Using metabolomics to investigate the impact of β-adrenergic signalling on cancer metabolism - Amanda L Peterson
Excessive HCK Kinase Activity in the Tumour Stroma Promotes Colorectal Cancer Progression - Ashleigh R Poh
E6AP, AN E3 UBIQUITIN LIGASE REGULATES THE TRANSCRIPTION OF CELL CYCLE INHIBITOR, p27 IN PROSTATE CANCER - Dinesh Raghu
Diagnostic use of array-Comparative Genomic Hybridisation (aCGH) to distinguish melanocytic naevi and melanoma in paraffin embedded tissue - Cleo Robinson
High Purity Isolation of Circulating Tumor Cells for Next Generation Sequencing - Nandor Roczo
TruePrime, a unique primer-free MDA technology for single cell amplification with low bias and superior variant recovery - Nandor Roczo
In situ Imaging and Quantitation of CD4+, CD8+ and FOXP3+ T Cells in Squamous Cell Carcinoma FFPE Sections - Justin Ross
Evaluation of selected immunomodulatory glycoproteins as an adjunct to cancer immunotherapy - Rebecca H Roubin
Ursolic acid micellar nanoparticles with enhanced anti-cancer activity - Rebecca H Roubin
Identification of a novel, actionable E2F:Sphk1:CRM1 axis that drives drug resistance in SCC patients - Alba Natalia Saenz-Ponce
Extracellular matrix mediated TGFβ signalling supports endometrial cancer metastasis - Subhransu Sahoo
Combined inhibition of RNA Polymerase I and the DNA damage response as a therapeutic strategy for p53 null cancers - Elaine Sanij
Role of Novel Extracts from Calendula officinalis in In-vitro Protection Against Cytotoxic and Chromosomal Damage by Reactive Oxygen Species (ROS). - Sunil Sapkota
Cancer Redox Stress Triggers a Rapid Intracellular Drug Resistance Mechanism - Nicole Seebacher
Targeting colon cancer stem cells with aptamer-guided siRNA - Hadi Shamaileh
Modelling Mutagenicity And Efficacy Of Direct Apoptosis Inducers - Tanmay Shekhar
TGF-β signalling in receptor-defective cancer cells by exosomal TGF-β - Jingyi Sheng
Dual inhibition of CDK4 and BRAF overcomes resistance and leads to sustained melanoma regression - Karen Sheppard
Stanniocalcin 2 and vimentin cooperate during formation and growth of in vitro ovarian cancer spheroids - Kristy Shield-Artin
Reverse Phase Protein Arrays – a powerful tool to study protein expression and modulation in high throughput - Kaylene J Simpson
Radioprotection by the combination of DNA binding antioxidants and aminothiol radical scavengers - Jai Smith
Functional genomics of BRAF-driven glycolysis in BRAF^V600melanoma - Lorey Smith
Dysregulation of Pol I transcription in ovarian cancer - Jinbae Son
Novel combination therapies targeting both RNA Polymerase I and Polymerase II transcription show synergistic efficacy in MLL-rearranged and core binding factor acute myeloid leukaemia - Jirawas Sornkom
AlphaLISA® SureFire® Ultra™ and AlphaPlex™ SureFire® Ultra™: rapid mix-and-read detection systems for cellular signalling pathways - Margareta Sutija
Identifying novel inhibitors to STAT3 mediated tumour progression - Fiona Tan
RNAi screens identify mutant p53 regulators - Kah Hin Tan
YAP is a promising target in cutaneous melanoma - JIAN ZHONG TANG
Effects of Cabozantinib on 5TGM1 myeloma cell dormancy in mice - Rachael L Terry
Targeting the Glycolytic Phenotype of Multiple Myeloma with Dichloroacetate - Dan Dan Tian
Immunophenotyping breast tissue for the identification of new immune-therapeutic targets for breast cancer - Ashleigh Unsworth
Advanced intravital imaging reveals targeting of tumour-stromal feedback via ROCK inhibition improves Gemcitabine & Abraxane efficacy in pancreatic cancer. - Claire Vennin
Synchrotron MRT radiation induces DNA damage and inflammatory response in normal mouce tissues distant from the irradiated volume - Jessica Ventura
Exploration of novel regulators of mutant p53 - Reshma Vijayakumaran
Breast cancer hijacks the brain and sets the scene for treatment-induced cognitive decline in survivors - Adam K Walker
TLR and BAFF signalling pathways as therapeutic targets in lymphoma - James Wang
MiR-198 represses tumor growth and metastasis in colorectal cancer by targeting fucosyl transferase 8 - Minyu Wang
Improving the accuracy of somatic variant detection in whole exome sequencing data by applying optimised filtering schemes - Paul Wang
Exosomes mediate amplification of TGF-β signalling in breast cancer cells - Yanhong Wang
The Role of EGFRvIII-STAT3 signaling in Glioblastoma Multiforme Progression - Thomas MB Ware
Optimising LOX-based ECM-targeted therapy in pancreatic cancer with Gemcitabine and Abraxane using live biosensor imaging - Sean C Warren
Functional genome-wide RNAi screens identify novel modifying genes of p53-mediated nucleolar stress response - Mei Szin Wong
Mismatch in epitope specificities between inflammatory and non-inflammatory conditions leads to escape from T lymphocyte killing in melanoma. - Katherine Woods
Genome-wide RNAi Screen for Synthetic Lethal Interactions with CX-5461 in Ovarian Cancer - Shunfei Yan
Targeting liver cancer stem cells with aptamer-drug conjugate - Wang Yin
Development of a functional assay for assessment of a predisposition to cancer risk in a sarcoma population based on constitutive defects in DNA repair - Xiaoyu Yin
The pro-survival protein MCL-1 and Triple Negative Breast Cancer - Adelaide Young
Characterising the immune profile of head and neck squamous cell carcinoma; prognostic significance of immune checkpoint inhibitors PD-L1 and IDO1 and correlation with HPV status - Richard J Young
Combined chemotherapy and immunotherapy in triple negative breast cancer - Chenhao Zhou
Modelling personalized medicine in high-risk neuroblastoma - Mitchell Lockwood
Dissecting the role of Guk-Holder in epithelial apical-basal cell polarity - Charlene Magtoto
Investigating the relative contribution of AURKA and AURKB inhibition to HPV-dependent cell killing in cervical cancer. - David Martin
Screening compounds from a South Australian Marine sponge for activity against human Chronic Lymphocytic Leukemia cell line. - Hana Masmali
The Role of Scribble in Erythropoiesis and Terminal Erythroid Differentiation - Kalpana Sivakumar

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Friday, 12th February 28th Lorne Cancer Conference 2016

Session 3 - Oncogenes and Tumour Suppressors

Morning Tea

Session 4 - Genomic Instability

Lunch

Session 5 - Tumour-Host Interactions

Dinner

Poster Session 2